ii) Outcome: ɛe<=13.4 %.

Current metabolites	Events/total	OR (95% CI)	p-value	Adjusted OR (95% CI) *	Adjusted p-value *
Short chain
C3	87/169	1.001 (1.0, 1.002)	0.52	-	-
C4	87/169	1.001 (1.0, 1.003)	0.66	-	-
C4-OH	87/169	1.05 (1.02, 1.09)	0.002	1.04 (1.006, 1.08)	0.0024
C5	87/169	1.01 (1.002, 1.02)	0.022	1.01 (1.001, 1.02)	0.024
C5:1	85/166	1.02 (0.97, 1.08)	0.39	-	-
Medium chain
C10:1	83/157	1.002 (1.0, 1.007)	0.39	-	-
C10:2	69/134	1.02 (0.98, 1.06)	0.32	-	-
C12-OH/C10-DC	87/169	1.70 (1.23, 2.33)	0.001	1.58 (1.13, 2.21)	0.008
C8:1-OH/C6:1-DC	87/169	0.99 (0.97, 1.02)	0.54	-	-
C8-DC	87/169	1.02 (1.0, 1.05)	0.062	-	-
Long chain
C14:1-OH	87/169	1.09 (1.01, 1.17)	0.019	1.07 (1.0, 1.16)	0.051
C14:3	87/169	1.05 (0.94, 1.18)	0.41	-	-
C14-OH/C12-DC	87/169	1.17 (1.06, 1.29)	0.002	1.13 (1.02, 1.25)	0.025
C16	87/169	1.004 (0.99, 1.02)	0.42	-	-
C16:1-OH/C14:1-DC	87/169	1.09 (0.94, 1.26)	0.28	-	-
C16:2-OH	87/169	1.19 (1.005, 1.41)	0.043	1.15 (0.96, 1.37)	0.13
C16:3-OH/C14:3-DC	84/161	1.78 (1.16, 2.71)	0.008	1.70 (1.10, 2.64)	0.018
C16-OH	87/169	1.07 (0.96, 1.18)	0.21	-	-
C18	87/169	0.99 (0.96, 1.02)	0.60	-	-
C18:1	87/169	1.003 (0.99, 1.01)	0.49	-	-
C18:1-OH/C16:1-DC	87/169	1.13 (0.98, 1.31)	0.10	-	-
C18:2	87/169	0.99 (0.98, 1.008)	0.33	-	-
C18:3	85/167	1.05 (0.91, 1.20)	0.52	-	-
C18-OH/C16-DC	87/169	1.15 (1.008, 1.32)	0.038	1.08 (0.95, 1.23)	0.25
C20	87/169	1.08 (0.90, 1.28)	0.42	-	-
C20:1	87/169	1.03 (0.92, 1.17)	0.59	-	-
C20:1-OH/C18:1-DC	87/169	1.05 (0.98, 1.14)	0.19	-	-
C20:2	87/169	1.01 (0.82, 1.24)	0.91	-	-
C20:2-OH/C18:2-DC	87/168	0.95 (0.76, 1.20)	0.67	-	-
C20:3	87/169	1.02 (0.90, 1.16)	0.75	-	-
C20:3-OH/C18:3-DC	81/159	1.13 (0.75, 1.72)	0.55	-	-
C20:4	87/169	1.008 (0.87, 1.17)	0.92	-	-
C22:1	87/169	1.08 (0.92, 1.26)	0.35	-	-
C22:2	81/160	1.29 (0.76, 2.18)	0.34	-	-
C22:4	85/166	0.83 (0.52, 1.32)	0.42	-	-
C22:5	85/167	1.10 (0.77, 1.56)	0.61	-	-

*adjusted for diabetes mellitus, female, BMI, CV rf>2.