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. 2021 May 25;13(11):15240–15254. doi: 10.18632/aging.203084

Figure 5.

Figure 5

SENP1 depletion promotes the inflammatory response and neuronal apoptosis under intermittent hypoxia (IH) condition. (A–C) The expression of IL-1β and TNF-α in hippocampus under normoxic and IH conditions were detected by (A) qRT-PCR and (B, C) western blot analysis. **p < 0.01, ***p < 0.001 versus the normoxia group. #p < 0.05, ##p < 0.01, ###p < 0.001 versus the SENP1+/+-IH group. (D, E) The expression of NF-κB p65, Bcl-2, Bax, Cleaved caspase-3 in hippocampus were detected by western blot analysis. *p < 0.05, ***p < 0.001 versus the normoxia group. ##p < 0.01, ###p < 0.001 versus the SENP1+/+-IH group.