Table 2.
Summary Table of Physiological, Subjective Drug Effects, and Cognitive Task Variables.
| Placebo | 10 mg | 25 mg | 50 mg | |
|---|---|---|---|---|
| Physiological | ||||
| Systolic Blood Pressure | 120.7 (0.8) | 118.6 (0.8) | 119.2 (0.9) | 118.2 (1.0) |
| Diastolic Blood pressure (mm/Hg) | 70.7 (0.6) | 70.7 (0.6) | 71.9 (0.7) | 71.7 (0.7) |
| Heart Rate (Beats per Minute) | 70.4 (0.7) | 76.2 (0.8) | 80.3 (1.2) | 83.2 (1.3) |
| Subjective Drug Effects (VAS, 0–100) | ||||
| Drug Effect | 2.3 (0.5) | 18.0 (1.8) | 38.3 (2.5) | 47.5 (2.7) |
| Unpleasant Drug Effect | 0.3 (0.3) | 3.2 (0.7) | 8.5 (1.2) | 13.3 (1.4) |
| Good Drug Effect | 3.5 (1.0) | 18.9 (1.9) | 34.9 (2.3) | 34.0 (2.3) |
| Sick | 0.4 (0.2) | 3.1 (0.6) | 3.3 (0.7) | 7.9 (1.0) |
| Heart Racing | 0.2 (0.1) | 1.7 (0.4) | 7.6 (1.2) | 14.9 (1.7) |
| Anxious/Nervous | 0.8 (0.2) | 1.8 (0.4) | 7.1 (1.1) | 12.5 (1.5) |
| Relaxed | 60.9 (2.4) | 65.1 (2.0) | 58.4 (2.2) | 52.1 (2.2) |
| Paranoid | 0.3 (0.1) | 1.5 (0.5) | 4.3 (1.0) | 11.0 (1.5) |
| Sleepy/Tired | 33.3 (2.1) | 39.4 (2.3) | 53.8 (2.0) | 57.0 (2.3) |
| Alert | 46.5 (2.4) | 42.6 (2.3) | 29.1 (2.0) | 30.3 (2.1) |
| Irritable | 1.2 (0.3) | 3.0 (0.7) | 3.0 (0.7) | 8.7 (1.1) |
| Vigorous | 28.6 (2.2) | 24.0 (1.9) | 16.5 (1.8) | 17.5 (1.7) |
| Restless | 3.7 (0.7) | 6.4 (1.0) | 10.5 (1.6) | 15.0 (1.9) |
| Hungry/Munchies | 7.6 (1.4) | 14.1 (1.7) | 17.1 (1.8) | 20.6 (2.0) |
| Craving Cannabis | 0.2 (0.1) | 0.7 (0.3) | 1.2 (0.5) | 0.7 (0.3) |
| Behavioral/Cognitive | ||||
| Divided Attention Task | ||||
| Average Distance from Target | 19.5 (0.6) | 23.6 (1.1) | 31.0 (1.7) | 35.0 (2.0) |
| Mean Overall Response | 1128.1 | 1168.4 | 1281.0 | 1286.3 |
| Time (ms) | (25.4) | (26.4) | (31.4) | (33.9) |
| Total Number Correct | 22.6 (0.1) | 21.9 (0.3) | 20.9 (0.3) | 20.5 (0.4) |
| Digit Symbol Substitution Task | ||||
| Total Attempted | 52.6 (0.6) | 52.9 (0.6) | 48.8 (0.7) | 46.0 (0.9) |
| Total Correct | 50.1 (0.6) | 49.2 (0.6) | 45.3 (0.7) | 41.9 (1.0) |
| Percent Correct | 95.3 (0.3) | 93.0 (0.5) | 92.6 (0.7) | 90.1 (1.1) |
| Paced Serial Addition Test | ||||
| Total Correct | 76.8 (1.1) | 73.8 (1.2) | 69.2 (1.7) | 64.4 (1.7) |
All values = mean (SD) peak scores.