Figure 3.

Panel A illustrates the relationship between alcohol doses and area under the alcohol concentration vs. time curve (AUC, mM•hr) in humans from three independent studies (Bauer et al., 1992; Mitchell et al., 2014; Mizoi et al., 1985). Panel B indicates the same relationship for mice from two independent studies (Carson and Pruett, 1996; Livy et al., 2003). The r² value for panel A is 0.989, and the r² value for panel B is 0.929. These are both significantly different from a slope of 0 (p < 0.0001), and the slopes for humans and mice are significantly different (p = 0.014). The same values are shown in panel C for ease of comparison, and the slope of the line for human samples and the slope of the line for mouse samples are significantly different (p = 0.014). The Table at the bottom of this Figure (D.) indicates the ratio of the dose in mice that produces a particular AUC value to the dose in humans that produces that same AUC value (calculated from Figure 1 C). For humans, all doses above 2 g/kg are extrapolated; for mice all values except the dose corresponding to 600 mM•hr were measured. The solid lines represent the regression lines calculated for the values shown and the dotted lines are the upper and lower 95% confidence intervals.