Skip to main content
. 2021 Jul;141(7):1664–1674.e7. doi: 10.1016/j.jid.2020.12.024

Figure 1.

Figure 1

The number of somatic mutations and mutation signatures across 37 AKs. (a) No. of nonsyn., syn., and UTR mutations across the 37 samples. (b) Box and whisker plot comparing the total No. of nonsyn. mutations per AK from IS patients with those from IC patients, showing significantly more mutations in IS patients (Wilcoxon, P = 0.03). (c) Mutation signature compositions across the 37 AK samples. Signature 32 = azathioprine signature, and Signatures 7a/7b = UVR signatures. AK, actinic keratosis; Aza, confirmed azathioprine exposure; IC, immunocompetent; IS, immunosuppressed; NC, no confirmed azathioprine exposure; No., number; syn., synonymous; UTR, untranslated region.