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. 2021 Jul;141(7):1664–1674.e7. doi: 10.1016/j.jid.2020.12.024

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Clonality analysis in AK. (a) EXPANDS clonality analysis showing clones and their percentages per sample. (b) Box and whisker plot comparing clone sizes between AK and cSCC. P = 0.00639. (c) Clonality analysis of 44 SMGs identifying clonal and subclonal nonsyn mutations using EXPANDS. AK, actinic keratoses; cSCC, cutaneous squamous cell carcinoma; EXPANDS, Expanding Ploidy and Allele-frequency on Nested Subpopulations; ID, identity; SCC, squamous cell carcinoma; SMG, significantly mutated gene; syn, synonymous.