Figure 2.

The tumor immune microenvironment (TIME). Several immune cells are found in the TIME, exhibiting either an immunostimulatory (CTLs, cytotoxic T cells, helper T cells, memory T cells, γδ T cells, NK T cells, plasma B cells, memory B cells, NK cells and M1-like TAMs) or immunosuppressive phenotype (Tregs cells, regulatory B cells, M-MDSCs, monocytic monocyte-derived suppressor cells, PMN-MDSCs, polymorphonuclear monocyte-derived suppressor cells and M2-like TAMs). The final immunological response in the TME will depend on the balance between these immunomodulatory populations.