Table 4. Gene-gene interaction between subgroups of patients with hepatitis C (<F2 n = 84 and ≥F2 n = 67) and relation of SNPs with the fibrosis.

Gene-gene interaction	p value	Median	p value adjusted	Median	Association
CARD8 rs2009373 vs IL18 rs187238
CARD8 T/T: G/C IL18	0.051	-0.633	0.028	-0.522	Protection
CTSB rs1692816 vs AIM2 rs1103577
CTSB A/A: C/T AIM2	0.060	-0.417	0.052	-0.413	Protection

Median: Median value (Average of minimum and maximum residues) generated by the statistical program R is the parameter that determines whether it is a risk or protection factor. Median values greater than 1 are associated with risk and less than 1 with protection; Adjusted p value: p value adjusted by gender and age. Fibrosis degree was assessed using METAVIR score. p < 0.05 is considered significant.