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Phases of the foreign body reaction. Proteins (including fibrinogen, albumin and complement proteins) adsorb to the biomaterial upon implantation. During acute inflammation neutrophils, shown in yellow, accumulate at the implantation site. In chronic inflammation macrophages, shown in pink, are attracted to the implantation site. Macrophages fuse into foreign body giant cells following frustrated phagocytosis. Finally, the biomaterial is encapsulated by fibrous tissue, shown in blue.
