Figure 8.
Regulation of HD-associated cell type identity modules by the PRC2. A, Cell type-specific expression of module eigengenes for 10 gene co-expression modules robustly enriched for PRC2 target genes. B, Change in expression of module eigengenes in cells from HttQ175/+ versus Htt+/+ mice; “+” and “–” indicate statistically significant upregulation or downregulation of eigengene expression in each cell types (adjusted p < 0.01). C, Over-representation of the genes in each module for PRC2 target genes defined by nine ChIP-seq experiments in embryonic stem cells (ESCs), MSNs, astrocytes (AS), and oligodendrocytes (OL). D, Over-representation of the genes in each module for upregulated and downregulated genes in MSNs from six-week-old, three-month-old, and six-month-old PRC2-silenced versus control mice.