Figure 1.

Kinetics of [¹¹C]erlotinib in mice. Total radioactivity concentration in venous plasma collected at the end of the PET scan, measured in a gamma counter in all examined mouse groups (a). Time-activity curves (mean ± SD) in whole brain (b), AUC_brain values (c) and V_T,brain values (d) for all examined mouse groups. For comparison, AUC_brain and V_T,brain values are also shown for Abcb1a/b^(−/−)Abcg2^(−/−) mice measured in a previous study.¹⁷ **p < 0.01; ***p < 0.001; ****p < 0.0001, one-way ANOVA with Dunnett’s multiple comparisons test.