Table 2.

CBF changes in AD mouse models.

Animal model	Mutation	Brain Region	CBF change (% decrease)	Age measured (months)	Age of cognitive deficits	Imaging modalities	Citation
J20	APP Swedish, Indiana	cortex	20	3	4	ASL-MRI	101
5xFAD	APP Swedish, Florida, LondonPSEN1 M146L and L286V	cortex	17	5–8	4	2PEF	97
TgCRND8	APP Swedish and Indiana	cortex	20	8	4	ASL-MRI	171
TgCRND8	APP Swedish and Indiana	cortex	25	7	4	ASL-MRI	159
APP/PS1Δ9	APP SwedishPSEN1 L166P	cortex, HC	24	6–7	6–9	ASL-MRI	97
APP knock-in	APP Swedish, Dutch, Londoncrossed in PS1 M146	cortex	21	8	8	ASL-MRI	100
PS2APP	APP SwedishPSEN PSEN2 N141I	cortex, HC	28	10	8–9	ASL (CASL) MRI	95
J20	APP Swedish, Indiana	cortex	45	16	4	Laser doppler	156
APP/PS1Δ9	APP SwedishPSEN1 L166P	cortex	28	15	6–9	Contrast enhanced MRI	106
APP/PS1Δ9	APP SwedishPSEN1 L166P	cortex	no change	0	6–9	Contrast enhanced MRI	107
APP/PS1	APP SwedishPSEN1 L166P	cortex	20	6	6–9	ASL-MRI	172
Tg1130H	APP695, V717I, V721A, M722V	cortex	20	2–3		Laser doppler	173
Tg2576	APP KM670/671NL	cortex	15	2–3	6	Laser doppler	148
APP/PS1Δ9	K594N/M595LPSEN1 L166P	cortex, HC	−20 (increase)	2–8	6–9	ASL-MRI	105
APOE4-TR	APOE Knock-In	Cortex, HC	35	9		autoradiography	109
APOE4-TR	APOE Knock-In	Cortex	20	3–4		ASL-MRI2PEF	108

Two-photon excited fluorescence microscopy (2PEF); arterial spin labeled MRI (ASL-MRI); Continuous ASL-MRI (CASAL); hippocampus (HC).