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. 2020 Dec 1;41(7):1692–1706. doi: 10.1177/0271678X20976412

Figure 3.

Figure 3.

Stroke outcome determined by MRI, histology and neurological test in lean and MS Cp old rats. (a) Infarct volume determined in lean/Cp rats at 3 and 7d after tMCAO measured in T2-WI (lean/Cp rats at 3d n = 24 respectively; lean/Cp rats at 7d n = 16 respectively). (b) Loss of cortex measured in lean/Cp animals at 28d after stroke by Nissl staining (n = 8 per experimental group). (c, d) BBB damage in lean/Cp rats at 3, 7 and 28d after tMCAO measured by DCE-MRI and IgG immunohistology (n = 8 per experimental group). (e, f) Motor and behavioral scores determined before and at 24 h, 3, 7, 14, 21 and 28d after cerebral ischemia in lean/Cp rats (lean/Cp basal, 24 h and 3d n = 24 per experimental group and time point; lean/Cp at 7d n = 16 per experimental group; lean/Cp at 14, 21 and 28d n = 8 per experimental group and time point). Data are expressed as mean±SD. *p < 0.05 vs lean, #p < 0.05 vs Lean-3d or Cp-3d, &p < 0.05 vs Cp-3d, &p < 0.05 vs Cp-7d, Student-t test and two-way ANOVA plus Bonferroni correction for single and multiple comparisons respectively. For the motor/behavioral analyses, data are expressed as the median and interquartile range, *p < 0.05 vs lean, Mann-Whitney test.