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. 2021 Jun 23;16(6):e0252617. doi: 10.1371/journal.pone.0252617

Table 1. Summary characteristics of included articles.

Characteristic Studies n (%)
Geographic scope
National 116 (12%)
Regional 347 (36%)
Local 277 (29%)
Sublocal 228 (24%)
Age groupsa
Children and Youth (0–17 years) 28 (3%)
Adults (18–64 years) 268 (28%)
Seniors (65+ years) 7 (0.7%)
Multiple age groups 609 (63%)
Population
Studies reporting population-wide estimates 590 (61%)
Studiesreporting population-specific estimatesb 378 (39%)
County income levelc
High income 747 (77%)
Low/middle income 221 (23%)
Sampling method
Probability sampling 209 (22%)
Non-probability sampling 759 (78%)
Antibody testsd
ELISA 242 (25%)
CLIA 409 (42%)
LFIA 137 (14%)
Other 10 (1%)
Neutralization 4 (0.4%)
Multiple types 37 (4%)
Antibody isotypes reportedd
IgG 845 (87%)
IgM 227 (24%)
IgA 47 (5%)
Risk of bias
Low 28 (3%)
Moderate 443 (46%)
High 424 (44%)
Unclear 73 (8%)

aWhen the age range for participants in a study overlapped multiple age categories by > = 30% then the study was counted as examining multiple age groups.

bStudies sampling from well-defined population sub-groups.

cClassified according to the WHO global burden of disease region groupings (high vs other—low/middle).

dStudies could have met multiple criteria so the sum of percentages may exceed 100%. Abbreviations: ELISA = enzyme-linked immunosorbent assay; CLIA = chemiluminescence immunoassay; LFIA = lateral flow immunoassay.