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. Author manuscript; available in PMC: 2022 Mar 23.
Published in final edited form as: Circulation. 2021 Jan 13;143(12):1184–1197. doi: 10.1161/CIRCULATIONAHA.120.049098

Figure 4: Receiver operator characteristics curve for %ddcfDNA to detect endomyocardial biopsy-diagnosed acute rejection.

Figure 4:

a) The area under the receiver operator characteristics curve (AUROC) for %ddcfDNA overtime for acute rejection (AR), AMR and ACR. Maximal test performance characteristics were noted from day 28. ROC characteristics for each pre-specified time are presented in Table 3 and Table IV in the Supplement.

b) AUROC of %ddcfDNA to detect acute rejection (AR), antibody mediated rejection (AMR, pAMR ≥1) or acute cellular rejection (ACR, grade ≥2R). Primary analysis excluded endomyocardial biopsies before day 28. 923 endomyocardial biopsies and concurrent ddcfDNA measures were included in this analysis. ROC characteristics are presented in Table 3.