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. 2021 May 13;12(6):3352–3371. doi: 10.1364/BOE.425512

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Fig. 5. — Structural and quantitative analyses of the necrotic regions in tumor spheroids based on intrinsic optical attenuation coefficient contrast. (A) Cross-sectional OCT image from the 50,000-cells OVCAR-8 spheroid on day 5. (B) Normalized intensity profile along the corresponding A-scan labelled by the red dashed line in A. (C) Histogram of the relative frequency of intrinsic optical attenuation coefficient. (D) Regions with high attenuation coefficients above the threshold superimposed with the original cross-sectional OCT image.