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. 2021 Jul;21(7):993–1003. doi: 10.1016/S1473-3099(20)30653-8

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© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Comparison of fold changes in histone trimethylation at the promoter region of proinflammatory cytokines over the first 6 weeks of life

Geometric mean fold change in percentage recovery of H3K4me3 (A) and H3K9me3 (B) at the promoter regions of TNF, IL6, and IL1B between birth (placental cord blood) and age 6 weeks, comparing infants randomly assigned to BCG at birth (BCG-vaccinated infants) with infants assigned to receive BCG at age 6 weeks (BCG-naive infants). GMRs of the fold change in percentage recovery of H3K4me3 (C) and H3K9me3 (D) comparing BCG-vaccinated infants with BCG-naive infants, by sex. GMR=geometric mean ratio.