Table 4.
Acceptability of the dapivirine vaginal ring at PUEV, based on all months of use, by country
| Malawi | South Africa | Uganda | Zimbabwe | Total | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N | (%) | N | (%) | N | (%) | N | (%) | N | (%) | |
| Total | 259 | (100) | 1136 | (100) | 238 | (100) | 637 | (100) | 2270 | (100) |
| PUEV study month—mean, median (IQR) | 14.4, 13 (11–16) | 20.3, 24 (13–27) | 21.9, 22 (19–27) | 18.9, 19 (13–24) | 19.4, 20 (13–27) | |||||
| Use attributes | ||||||||||
| Problematic change to vaginal environmenta | 19 | (7) | 125 | (11) | 19 | (8) | 24 | (4) | 187 | (8) |
| Vagina wetter | 13 | (5) | 109 | (10) | 13 | (5) | 20 | (3) | 155 | (7) |
| Vagina drier | 6 | (2) | 16 | (1) | 6 | (3) | 4 | (1) | 32 | (1) |
| Mind wearing the ring during mensesa | 90 | (35) | 93 | (8) | 183 | (77) | 6 | (1) | 372 | (16) |
| Did not have menses during the study | 24 | (9) | 147 | (13) | 20 | (8) | 26 | (4) | 217 | (10) |
| Effects on sex | ||||||||||
| Mind wearing the ring during sexa | 90 | (35) | 109 | (10) | 203 | (85) | 2 | (< 1) | 404 | (18) |
| Did not have sex during the study | 4 | (2) | 13 | (1) | 0 | (0) | 1 | (< 1) | 18 | (1) |
| Ring's effect on sexual pleasurea,b | ||||||||||
| Increases sexual pleasure | 152 | (59) | 358 | (32) | 85 | (36) | 283 | (44) | 878 | (39) |
| Decreases sexual pleasure | 4 | (2) | 44 | (4) | 10 | (4) | 3 | (1) | 61 | (3) |
| No change to sexual pleasure | 99 | (38) | 719 | (63) | 143 | (60) | 350 | (55) | 1311 | (58) |
| Partner’s attitude | ||||||||||
| Ring was acceptable to partnera | ||||||||||
| Yes | 231 | (89) | 794 | (70) | 101 | (42) | 484 | (76) | 1610 | (71) |
| No | 15 | (6) | 142 | (13) | 59 | (25) | 34 | (5) | 250 | (11) |
| Don’t know | 13 | (5) | 199 | (18) | 78 | (33) | 119 | (19) | 409 | (18) |
| Partner ever asked you to stop wearing the ringa | 20 | (8) | 158 | (14) | 27 | (11) | 34 | (5) | 239 | (11) |
| Overall acceptability, future likelihood of ring usea,c | ||||||||||
| Very likely | 149 | (58) | 673 | (59) | 185 | (78) | 496 | (78) | 1503 | (66) |
| Likely | 82 | (32) | 398 | (35) | 49 | (21) | 140 | (22) | 669 | (30) |
| Unlikely | 16 | (6) | 28 | (3) | 2 | (1) | 1 | (0) | 47 | (2) |
| Very unlikely | 12 | (5) | 36 | (3) | 2 | (1) | 0 | (0) | 50 | (2) |
PUEV product use end visit, IQR interquartile range
aSignificantly different by country, p < 0.001
bMissing response: Malawi (N = 4), South Africa (N = 15), Zimbabwe (N = 1)
cMissing response: South Africa (N = 1)