Table 1.

Dosing and Costs of Antipsychotics and VMAT-2 Inhibitors Used to Treat Chorea in the United States

Class	Medication	FDA Indicated for HD chorea?	Adult dosing1			Benefit for psychiatric symptoms?	Available generic?	Cost for 30-day supply of lowest target dose2
			Initial daily dose	Target daily dose	Divided dose?
Atypical antipsychotics3	risperidone	no	2–3 mg	1–8 mg	yes	yes	yes	$1.50
	olanzapine	no	5–15 mg	5–20 mg	no	yes	yes	$4.50
	aripiprazole	no	10–15 mg	10–15 mg	no	yes	yes	$11.18
	clozapine	no	12.5 mg	300–600 mg	yes	yes	yes	$32.63
	quetiapine	no	25–100 mg	50–800 mg	yes	yes	yes	$7.80
VMAT-2 inhibitors	tetrabenazine	yes	12.5 mg	25–100 mg	yes	no	yes	$430.77
	deutetrabenazine	yes	6 mg	6–48 mg	yes	no	no	$1,916.15
	valbenazine	no	40 mg	80 mg	no	no	no	$6,649.835

¹Antipsychotic and valbenazine dosing includes monotherapy dose range for all approved indications according; tetrabenazine and deutetrabenazine include only HD approved doses.

²Cost estimates are from www.goodrx.com. Costs are lowest listed costs, not accounting for insurance coverage, including available coupons and mail order prices listed on www.goodrx.com as of 10/6/20. For brand name medications, coupons and patient assistance programs typically lower the price, but this is dependent on patient insurance.

³First generation antipsychotics and therapies not approved in the US are not included on this list, as we aimed the include the most relevant agents. All antipsychotics listed refer to immediate release oral formulations.

⁴GoodRx pricing was available only for the starting dose pack, not for the 80 mg target dose