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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Am J Psychiatry. 2021 Jan 5;178(6):509–521. doi: 10.1176/appi.ajp.2020.20030340

Figure 2: Mechanistically plausible neuroimaging biomarker development targets.

Figure 2:

Based on discovery oriented research a number of mechanistically plausible neuroimaging biomarker development targets have been identified. Diagnostic biomarkers aid in the detection of the presence of a disease state. Target engagement biomarkers confirm therapeutic properties of drugs and can be used for determination of appropriate dosing. Treatment response predication biomarkers guide the appropriate choice of treatment. Therapeutic monitoring biomarkers monitor the response to a specific treatment or monitor relapse of a disorder.