Table 1.

Selected lncRNAs involved in stroke pathogenesis.

LncRNA	Target (s)	Effect (s)	Study models	Ref
N1LR	Maybe inactivates p53	Inhibits neural death and apoptosis probably via reducing p53 phosphorylation	In vitro: N2a cells In vivo: SD rats, mice	[76]
MALAT1	E-selectin and Bim	Inhibits inflammation and endothelial cell death and defends cerebral parenchyma and microvasculature from brain ischemic injury.	In vitro: BMECs In vivo: C57BL/6 mice	[83]
H19	DUSP5-ERK1/2	Silenced autophagy which activated by OGD/R via DUSP5-ERK1/2 axis.	In vitro: SH-SY5Y cells In vivo: SD rats	[84]
TUG1	miR-9/Bcl2l11	Inhibits miR-9 and weakened suppression of bcl2l11 expression and so, leads a neurotoxicity after stroke.	In vitro: SH-SY5Y cells In vivo: SD rats	[85]
C2dat1	CaMKIIδ	Increases the CaMKIIδ expression and activates NF-κB signal impacting neuronal survival after ischemic stroke.	n vitro: N2a cells In vivo: C57BL/6 mice	[86]
ANRIL	VEGF/NF-κB	Increases VEGF expression and activates angiogenesis via activation of NF-κB pathway	In vivo: male Wistar rats	[87]