Table 1.

Statistical overview of variant interactions investigated.

	Lipid metabolism pathway	Extracellular matrix pathway	Immune pathway
Independent signalsa	7	15	19
Combinations	127	32,767	524,287
Tests (24,123 genes)	3 M	790 M	12.6 B
Significance threshold	Q-value < 0.05	Q-value < 0.05	P-value < 10–5
Significant results	2	0	641,016
eUnique eCombinations	2	0	326,144
Unique eGenes	1	0	1725

^aIndependent signals = independent AMD-associated genetic variants as defined by Fritsche et al.²