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. 2021 Jun 23;6:88. doi: 10.1038/s41541-021-00344-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Impact of TT adsorption on alum and antigen concentration on anti-TT IgG production in buffy coat donors. a Comparison of response to TT adsorbed vs non-adsorbed (0.0025 Lf/ml) (14 donors; n = 7 independent experiments), b correlation of the enzymatic activity of anti-TT IgG in response to TT adsorbed and non-adsorbed (0.0025 Lf/ml) of individual donors (each represented as a single dot), c titration of TT adsorbed (left panel) (12 donors; n = 7 independent experiments) and titration of TT non-adsorbed (right panel) (11 donors; n = 7 independent experiments). d Comparison of the enzymatic activity of anti-TT IgG in response to two different batches from the same manufacturer (17 donors; n = 4 independent experiments) and e correlation of the means of enzymatic activity of anti-TT IgG of the individual donors in response to the batch #1 and #2 (each donor represented as a single dot) (n = 4 independent experiments). f Comparison of the enzymatic activity of anti-TT IgG in response to adsorbed TT from two different manufacturers (14 donors; n = 3 independent experiments) and g correlation of the means of enzymatic activity of anti-TT IgG of the individual donors in response to the TT adsorbed from Manufacturer #1 and #2 (each represented as a single dot). Bar graphs represent mean (± standard deviation) of the enzymatic activity means of all donors. The dotted line shows anti-TT IgG enzymatic activity of 200, the threshold of reactivity. Data were analyzed using Wilcoxon matched-pairs signed rank test and Spearman correlation. P values are depicted in the respective graphs, ns non-significant.