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. 2021 Jun 23;6:88. doi: 10.1038/s41541-021-00344-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Anti-TT IgG enzymatic activity in response to CpG + DTaP and DaP vaccine without TT in buffy coat donors. Combined values of enzymatic activity from 10 buffy coats donors with statistical evaluation (Wilcoxon matched-pairs rank test) (n = 4 independent experiments). Bar graphs represent mean (± standard deviation) of the enzymatic activity means of all donors. The dotted line shows anti-TT IgG enzymatic activity of 200, the threshold of reactivity. P values are depicted in the respective graphs, ns non-significant.