Table 2.
Vaccinated donors’ characteristics.
| Number | Sex | Age | Time since last TT vaccination (years) | Blood taken after vaccination (days) | Anti-TT IgG titer in plasma before vaccination (IU/ml) | Anti-TT IgG titer in plasma after vaccination (IU/ml) | Switched memory B cells in 1 Mio PBMC before vaccination | Switched memory B cells in 1 Mio PBMC after vaccination |
|---|---|---|---|---|---|---|---|---|
| Donor #1 | M | 26 | 13 | 26 | 1,3 | 9,9 | 10,015 | 10,323 |
| Donor #2 | F | 34 | 9 | 26 | 0,6 | 12,0 | 12,928 | 16,037 |
| Donor #3 | M | 34 | 23 | 15 | 0,7 | 1,5 | 16,639 | 21,350 |
| Donor #4 | M | 47 | 9 | 18 | 1,2 | 3,9 | 7798 | 11,684 |
| Donor #5 | M | 33 | 6 | 15 | 1,4 | 3,6 | 17,079 | 18,386 |
| Donor #6 | F | 55 | 7 | 18 | 6,6 | 7,1 | 7914 | 7242 |
| Donor #7 | M | 47 | 5 | 20 | 1,2 | 3,9 | 13,996 | 13,577 |
| Donor #8 | F | 26 | 8 | 14 | 0,9 | 9,9 | 13,834 | 12,377 |
| Donor #9 | F | 25 | 9 | 20 | n.a. | 8,4 | n.a. | 11,945 |
| Donor #10 | F | 25 | 8 | 13 | 1,2 | 10,5 | 12,828 | 10,895 |
| Donor #11 | M | 58 | 10 | 7 | 0,6 | n.a. | 9749 | 7289 |
PBMC from donors #4, #6, and #8 after vaccination did not respond to CpG + TT in the assay.