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. 2021 Jun 23;11:13192. doi: 10.1038/s41598-021-92335-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sensitivity and specificity analysis. Gene panel based on the top 10 most significant genes by adjusted p-value. The 95th centile is calculated for each gene using the outputs of Non and Focal-PNI samples. The 95th centile score is subtracted from each sample. Fields that are positive (i.e. > 95th centile) are given a score of 1 and are shaded orange. The total score is then calculated across all 10 genes to give a combined score out of 10. Outliers (shaded blue) are determined as any Non or Focal-PNI samples with a score of > 1, or Extensive PNI with a Score < 2.