Figure 3.
Sensitivity and specificity analysis. Gene panel based on the top 10 most significant genes by adjusted p-value. The 95th centile is calculated for each gene using the outputs of Non and Focal-PNI samples. The 95th centile score is subtracted from each sample. Fields that are positive (i.e. > 95th centile) are given a score of 1 and are shaded orange. The total score is then calculated across all 10 genes to give a combined score out of 10. Outliers (shaded blue) are determined as any Non or Focal-PNI samples with a score of > 1, or Extensive PNI with a Score < 2.