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. 2021 Jun 23;11:13163. doi: 10.1038/s41598-021-89451-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mouse Phenotyping (a) Study design. (b) Echocardiography: Representative 2D and M-mode images from mutants (MyHC, TnT) and respective littermate control mice (ContM, ContT) illustrate that Left Ventricular (LV) cavity size is smaller in TnT-mutant mice, and larger in MyHC-mutant mice, when compared to littermate-controls. (c) Representative gross anatomy (left panel) and histology images (right panel) from mutants (MyHC, TnT) and littermate controls (ContM, ContT) reveal larger heart size in MyHC-mutants, and smaller heart size in TnT-mutants, when compared to littermate-controls. Bi-atrial enlargement is prominent in TnT-mutant mice. (d) Picrosirius Red staining reveals higher interstitial fibrosis in both mutant mouse hearts when compared to littermate-control hearts (for gross anatomy, calibration markers are 1 mm; microscopy calibration marker indicates 50 μm). For complete list of data with statistical analysis please see Table 1.