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. 2021 Jun 23;11:13163. doi: 10.1038/s41598-021-89451-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Global mRNA-seq analysis of MyHC and TnT-mutant mouse hearts and human-HCM. (a) Volcano plots of mRNA expression. X-axis shows mean of normalized counts among the 6 biological samples tested (3 biological replicates each for two genotypes compared in each graph) and Y-axis shows log2(fold-change) in the normalized counts. (b) Venn diagram of the numbers of differentially expressed genes. (c) Heatmaps of log2(fold-change) of mRNA expression levels in MyHC-mutant and TnT-mutant mouse hearts compared with littermate-control hearts for the 150 and 186 genes that are differentially expressed (adjusted p < 0.05) in either MyHC or TnT-mutant mice, respectively (means of three biological replicates are presented). The genes are sorted based on log2(fold-change) in MyHC-mutant mice (left panel) or in TnT-mutant mice (right panel). (d) Heatmap of log2(fold-change) of top 20 upregulated genes and downregulated genes in MyHC-mutant mice compared to littermate-controls (means of three biological replicates are presented). (e) Heatmap of log2(fold-change) of top 20 upregulated and downregulated genes in TnT-mutant mice compared to littermate-controls (means of three biological replicates are presented). (f) Heatmap of log2(fold-change) of top 20 upregulated and downregulated genes in human myectomy tissue compared to control hearts (means data is presented; n = 105 HCM patients/n = 39 controls).