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. 2021 Jun 23;11:13163. doi: 10.1038/s41598-021-89451-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differential metabolic gene expression in MyHC and TnT-mutant mouse hearts and human-HCM. (a) Heatmap of log2(fold-change) of normalized mRNA reads in MyHC-mutant and TnT-mutant mouse hearts compared with littermate-control hearts. mRNAs are clustered depending on the metabolic function of the involved metabolic genes (Krebs cycle, Fatty Acid metabolism, Glucose use, BCAA, OxPhos). Means of three biological replicates are presented. (b,c,e) Volcano plots of normalized mRNA reads of metabolic genes in MyHC-mutant and TnT-mutant mice compared to littermate-controls and in human myectomy tissue and control-hearts. Benjamini–Hochberg method was used to adjust p values for multiple comparisons; n = 3 biological replicates. (d) Heatmap of log2(fold-change) of normalized mRNA reads in human myectomy tissue compared to control-hearts (means are presented; n = 105 HCM patients/n = 39 controls). mRNAs are clustered depending on the metabolic function of the involved metabolic genes (Krebs cycle, Fatty Acids, Glucose use, BCAA, OxPhos).