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. 2021 Jun 23;11:13163. doi: 10.1038/s41598-021-89451-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ingenuity pathway analysis: top 5 dysregulated signaling pathways (a), transcriptional factors (b) and therapies (c) are presented for MyHC-mutant (1) TnT-mutant (2) mouse hearts, and human myectomy tissue (3). All comparisons are made to corresponding controls. Cutoff value for significance of p < 0.01 and |Z-score|> 1. Comparison of mRNA data from mutant HCM mice and human myectomy samples with respective controls was performed by ANOVA using the Partek Genomics Suite 7.0 platform.