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. 2021 Jun 23;11:13163. doi: 10.1038/s41598-021-89451-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Genes implicated in cardiac hypertrophy and its regulation: volcano plots of normalized mRNA reads in MyHC and TnT-mutant mouse hearts (a,b) and human myectomy tissue (c). Heatmap of log2(fold-change) of differentially expressed genes related to hypertrophy and its regulation in MyHC-mutant and TnT-mutant mouse hearts (d) and in human myectomy tissue (e) compared to respective controls. Benjamini–Hochberg method was used to adjust p values for multiple comparisons; n = 3 biological replicates for mouse data; n = 105 HCM patients/n = 39 controls for human data). Genes involved in TGF-β signaling pathway and its regulation: Volcano plots of normalized mRNA reads of TGF-β pathway related genes in MyHC-mutant and TnT-mutant mouse hearts (a,b) and human myectomy tissue (c). Heatmap of log2(fold-change) of differentially expressed genes related to TGF-β signaling pathway and its regulators in MyHC-mutant and TnT-mutant mouse hearts (d) and in human myectomy tissue (e) compared to respective controls. Benjamini–Hochberg method was used to adjust p values for multiple comparisons (n = 3 biological replicates for mouse data; n = 105 HCM patients/n = 39 controls for human data).