Table 2.

List of select processes identified by KEGG^a and GO analysis in 24 weeks old mutant mice and human myectomy tissue.

R403Q-MyHC mouse heart	p value	R92W-TnT mouse	p value	Human myectomy tissue	p value
KEGG
Endocrine and other factor-regulated calcium reabsorption	0.003	Val, Leu, Ile degradation	5.8E−6	Phagosome	3E−11
Pyruvate metabolism	0.01	Propanoate metabolism	0.001	Val, Leu, Ile degradation	9E−7
Glycerolipid metabolism	0.03	Fatty acid degradation	0.004
N-Glycan biosynthesis	0.03	Pantothenate and CoA biosynthesis	0.006	Viral myocarditis	2E−5
Regulation of lipolysis in adipocytes	0.047	Insulin signaling pathway	0.01	Carbon metabolism	0.0002
		Pyruvate metabolism	0.02	Apoptosis	0.0006
		Cellular senescence	0.03	Propanoate metabolism	0.0006
		Fatty acid metabolism	0.04	HIF-1 signaling pathway	0.0007
		Phosphatidylinositol signaling system	0.04	Insulin resistance	0.001
		Insulin resistance	0.048	Pyruvate metabolism	0.002
GO cellular component
Intrinsic component of organelle membrane	0.01	Mitochondrial matrix	3.4E−9	Contractile fiber	1.8E−9
Polysome	0.04	Oxidoreductase complex	4.8E−5	Cell-substrate junction	4.5E−9
		Mitochondrial protein complex	5.3E−5	Mitochondrial substrate	3.1E−5
		Organelle inner membrane	0.001	Actin cytoskeleton	7.2E−5
		Mitochondrial membrane part	0.02	ATPase complex	0.03
		NADH dehydrogenase complex	0.04	Mitochondrial inner membrane	0.03
GO molecular function
ADP binding	0.006	Coenzyme binding	1.9E−4	Cofactor binding	4.1E−7
Single stranding DNA binding	0.01	Oxidoreductase activity on the CH-CH group of donors	0.0010	Cell adhesion molecule binding	1.5E−5
Basal transcription machinery binding	0.03	Electron transfer activity	0.002	Sulfur compound binding	1.5E−5
RNA polymerase II transcription factor binding	0.03	Oxidoreductase activity on the aldehyde or oxo group of donors	0.003	Oxidoreductase activity	1.9E−5
Ribonucleoprotein complex binding	0.04	Sulfur compound binding	0.004	Collagen binding	0.0001
Carboxylic ester hydrolase activity	0.04	Lipase activity	0.007	Electron carrier activity	0.0002
Catalytic activity acting on DNA	0.04	Carboxylic ester hydrolase activity	0.02	Oxidoreductase activity on CH-CH donors	0.0003
GO biologic process
Neutral lipid metabolic process	3.9E−4	Fatty acid metabolic process	2.7E−6	Blood vessel morphogenesis	2.3E−9
Cell redox homeostasis	0.002	Small molecule catabolic process	1.2E−5	Negative regulation of growth	1.6E−8
Regulation of binding	0.005	Lipid modification	1.7E−5	Response to inorganic substance	4.4E−8
Glycerolipid metabolic process	0.006	Generation of precursors metabolites and energy	2.5E−5	Cofactor metabolic process	4.5E−8
DNA-templated transcription termination	0.008	Lipid catabolic process	1.6E−4	Actomyosin structure organization	8E−8
Response to temperature stimulus	0.01	Nucleoside biphosphate metabolic process	4.8E−4	Cellular metal ion homeostasis	1.2E−7
		Cellular amino acid metabolic process	0.002	Regulation of vasculature development	1.9E−7
		Organophosphate biosynthetic process	0.004	Plasma membrane organization	2E−7

Benjamini–Hochberg method was used to adjust p values for multiple testing.

^aKanehisa and Goto⁶⁴, Kanehisa⁶⁵, Kanehisa et al.⁶⁶.