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. 2021 Jun 23;5:58. doi: 10.1038/s41698-021-00194-z

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The definition of evidence tiers in TOPOGRAPH reflects the maturity of a drug in its development. Tiers T1, T2, and R1 are considered standard-of-care, whereas the remaining tiers are investigational. Therapy yet to be adequately studied for possible clinical activities are designated T4. BM biomarker; Ph2 phase 2 clinical trials, Ph3 phase 3 clinical trials, SOC standard of care.