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. 2021 Jun 23;12:3867. doi: 10.1038/s41467-021-23943-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The impact of substitutions as they are accumulated along the projected adaptive trajectory in each metal environment. Colored dots indicate the corresponding metal environment’s “end point” for the projected trajectory beginning at the ancestral DHCH genotype. Genotypes are labeled using a binary system, with “0” indicating the residue being in the ancestral state and “1” indicating the residue being in the derived state and are ordered according to the order of the residues in the enzyme sequence (e.g., the first number indicates the state of position 72, the second the state of position 193, the third the state of position 258 and so on).