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. 2021 Jun 23;12(7):642. doi: 10.1038/s41419-021-03930-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Western blot and statistical analysis of the effect of TXNIP overexpression (OE) on LC3 and Bax in RSC96 cells. *P < 0.05 versus negative control group (NC). B Immunofluorescence of cleaved Caspase 3 in RSC96 cells transfected with negative control plasmid and TXNIP overexpression plasmid. Bar: 10 μm. C Western blot and statistical analysis of the effect of TXNIP knockdown using shRNA plasmid (pGenesil-1-TXNIP) on LC3 and cleaved Caspase 3 in RSC96 cells. *P < 0.05 versus normal glucose group. # means P < 0.05 versus high glucose group. D Immunofluorescence of LC3 in RSC96 cells transfected with control plasmid and TXNIP shRNA plasmid. The inset was shown with dashed square. White arrows showed the clustered LC3 expression. Bar: 10 μm. E Immunofluorescence of cleaved Caspase 3 in RSC96 cells transfected with control plasmid and TXNIP shRNA plasmid. White arrows showed the positive expression. Bar: 10 μm. F Immunofluorescence of Bax in RSC96 cells transfected with control plasmid and TXNIP shRNA plasmid. White arrows showed the positive signal. Bar: 10 μm.