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. 2021 Jun 23;12(7):642. doi: 10.1038/s41419-021-03930-2

Fig. 7. Knockout of TXNIP in vivo ameliorated cell autophagy and improved nerve conduction function in the sciatic nerve of diabetic mice.

Fig. 7

A, B Electrophysiological detection of action amplitude and conduction velocity of the sciatic nerves of diabetic mice with TXNIP (+/+) and TXNIP (−/−). *P < 0.05 versus normal mice. #P < 0.05 versus TXNIP (+/+) diabetic mice. C Electron microscope observation of myelin sheath in the sciatic nerves of diabetic mice with TXNIP (+/+) and TXNIP (−/−). Black arrows showed infoldings. Bar: 1000 nm. D Immunohistochemistry of LC3 in the sciatic nerves of diabetic mice with TXNIP (+/+) and TXNIP (−/−). The inset was shown with dashed square. Bar: 50 μm. E Immunohistochemistry of cleaved Caspase 3 in the sciatic nerves of diabetic mice with TXNIP (+/+) and TXNIP (−/−). The inset was shown with dashed square. Bar: 50 μm. F Immunohistochemistry of Bax in the sciatic nerves of diabetic mice with TXNIP (+/+) and TXNIP (−/−). The inset was shown with dashed square. Bar: 50 μm. G Model of the regulation of high glucose on the phospho-Akt, DNMTs, TXNIP, apoptosis, and autophagy in Schwann cells.