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. 2021 Jun 23;12:3883. doi: 10.1038/s41467-021-24199-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The DNA-binding modules in each subunit are labeled around the DNA sequence: the initiator-specific motif (ISM) of the AAA+ domains, the β-hairpin or/and HTH-motif of the WHD domain, and the basic residue patch (BP). Nucleotides in red are the extended footprint in ORC–Cdc6 relative to ORC alone. b Structure of the DNA-binding modules around the ACS element. c Structures of DNA-binding modules around the B1 element of the origin DNA.