Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 23;12:3883. doi: 10.1038/s41467-021-24199-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a Conformational changes of the Cdc6 WHD during the loading of Mcm2-7 from ORC–Cdc6 to semi-attached OCCM to pre-insertion OCCM and to the DNA-inserted OCCM. The dashed black circle in the last panel encircles the Cdc6 WHD binding region; this region is enlarged in panels (b–d) and shown in different views. b, c The Cdc6 WHD rotates (b) and shifts (c) relative to the Orc1 AAA+ domain. d The repositioned Cdc6 WHD in OCCM inserts Lys-479 and Lys-483 into the now straightened ACS DNA groove. In panels (b–d), the Cdc6 WHD is shown as solid purple in the ORC–Cdc6 and as transparent purple in the OCCM structure.