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. 2021 Jun 23;4:775. doi: 10.1038/s42003-021-02291-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Representative images of the intercalated disc in the heart of HHWT (Elmo1^H/H Ins2^+/+) and HHAkita (Elmo1^H/H Ins2^Akita/+) mice in the transmission electron microscopy. Arrowheads indicate the dissociation of intercalated discs. Scale bar = 1 μm. b Proportion of the dissociated intercalated discs. c Apparent size of mitochondria (mito.) were scored from at least 30 mitochondria in each animal. d Citrate synthase activity in the heart. e Mitochondrial complex I activity. f Mitochondrial complex IV activity. g Mitochondrial complex V activity. Data are expressed as means ± standard errors. N = 6 in each group. *P < 0.05 vs. untreated (Untr) HHWT mice by Tukey–Kramer Honestly Significant Differences test after one-way ANOVA; †P < 0.05 vs. untreated HHAkita mice; ‡P < 0.05 vs. B12-treated HHAkita mice.