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. 2021 Jun 23;12:3899. doi: 10.1038/s41467-021-24095-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Venn diagrams showing the numbers of genes significantly up- or down-regulated (±log₂ 2 and adjusted p-value <0.05) in the eed1Δ/Δ mutant compared to WT (SC5314) with citrate or CAA as sole carbon source. Genes referred to in the text are highlighted. b Morphology of C. albicans WT and eed1Δ/Δ mutant after 12 h of growth on citrate or CAA. Representative pictures from three biologically independent experiments are shown. Scale bar represents 20 µm and applies to all images. c Network analysis of Gene Ontology (GO) term enrichments of significantly up-regulated genes (+ log₂ 2 and adjusted p-value <0.05) in eed1Δ/Δ mutant compared to WT after 12 h of growth on citrate. Font size represents the p-value (p < 0.1) of the GO term: big letters – small p value, ranging from p < 2.3 × 10⁻⁵ to low p-value p < 0.09 indicated by small letters. Color is representing the uniqueness, indicating how particular each term is with respect to the set of terms being evaluated (original data analyzed are available in Supplementary Data 1).