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. 2021 Jun 23;11:13157. doi: 10.1038/s41598-021-92561-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Co-stimulation of HDM and STING ligand increased the serum IgE levels. (A) Strategy of HDM- and cGAMP-co-stimulated mice. (B) Total number of cells in BALF collected from the indicated mice. Saline + saline-treated mice: N = 3, cGAMP + saline-treated mice: N = 3, saline + HDM-treated mice: N = 5, and cGAMP + HDM-treated mice: N = 5. (C, left) Dot plots show the percentage of eosinophils (11b+, 11c−, SiglecF+) and neutrophils (11b+, 11c−, Ly6G+) in BALF from stimulated mice. (C, right) These cells were statistically analyzed. Saline + saline-treated mice: N = 3, cGAMP + saline-treated mice: N = 3, and saline + HDM-treated mice: N = 3, and cGAMP + HDM-treated mice: N = 3. (D) The percentage of B cells in BALF from stimulated mice. Saline + HDM-treated mice, N = 7 and cGAMP + HDM-treated mice, N = 6. (E) Total (left) and HDM-specific IgE levels in serum from stimulated mice. Saline + saline-treated mice: N = 3, cGAMP + saline-treated mice: N = 3, saline + HDM-treated mice: N = 8, and cGAMP + HDM-treated mice: N = 8 for total IgE levels. Saline + saline-treated mice: N = 3, cGAMP + saline-treated mice: N = 3, saline + HDM-treated mice: N = 8, and cGAMP + HDM-treated mice: N = 8 for HDM-specific IgE levels. (F) Serum IgE capture assay in the indicated mice. Saline + saline-treated mice: N = 3, cGAMP + saline-treated mice: N = 5, saline + HDM-treated mice: N = 7, and cGAMP + HDM-treated mice: N = 6. Data are presented as the mean ± SD and are representative of three independent experiments. i.t. intratracheally, n.s not significant, Neu neutrophils, Eo eosinophils.