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. 2021 Jun 23;11:13096. doi: 10.1038/s41598-021-92586-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the three types of changes in CBV during HI insult and after insult according to severity of insult. (A) In mild insults, CBV falls slightly during the insult and decreases to baseline after resuscitation. (B) In moderately severe insults, CBV decreases during the insult above the baseline and decreases after resuscitation to a smaller extent than in (A). (C) In severe insults, CBV falls during the insult to below the baseline and increases after resuscitation. The angles of the CBV changes from the basal horizontal line after resuscitation are α < β < γ (the angle values of α and β are negative, whereas that of γ is positive).