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. 2021 Jun 10;12:613630. doi: 10.3389/fneur.2021.613630

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Copyright © 2021 Black, King, Mahan, Anderson and Butson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased activation in NP subjects during the pain focus state compared to the non-pain focus state. T-statistic mapping of increased BOLD activation (p < 0.05 uncorrected) during the pain focus state when compared to the non-pain focus state in the NP subject group. Increased activity was seen bilaterally in precuneus, anterior insula, middle temporal gyrus, middle cingulate cortex, and orbitofrontal cortex, and unilaterally in the left lingual gyrus. Clusters fewer than 10 contiguous voxels were filtered for clarity. The difference between axial slices is 5 mm and z-values are relative to the AC/PC plane.