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. 2021 Jun 10;12:613630. doi: 10.3389/fneur.2021.613630

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Copyright © 2021 Black, King, Mahan, Anderson and Butson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regions with increased connectivity to pain, foot, and hand association regions in NP subjects compared to controls. Regions within the 361 combined parcellation showing increased connectivity (p < 0.05 uncorrected) with individually defined regions associated with pain, foot, and hand in NP subjects when compared to controls. Hyperconnectivity was seen between the pain region and parts of the dorsal attention, ventral attention, and somatomotor networks. The foot region showed increased connectivity with parts of the cingulo-opercular, dorsal attention, fronto-parietal, and somatomotor networks. The hand region showed increased connectivity with default, dorsal attention, fronto-parietal, ventral attention, and somatomotor networks. Lateral (top left and right), medial (middle left and right), anterior (bottom left), posterior (bottom right), superior (top middle), and inferior (bottom middle) views are shown.