FIGURE 4.

SCR7 tilts the balance toward HR during genome editing. Incubation of SCR7 and CRISPR/Cas9 mixture with mammalian cells leads to inhibition of nonhomologous end‐joining and thus, the DSB repair occurs primarily only through HR. In the absence of c‐NHEJ, the cell is dependent on HDR for mending the broken ends that result in an error‐free repair of the target site