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. 2021 Jun 10;12:675255. doi: 10.3389/fneur.2021.675255

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Copyright © 2021 Wolf, Gerloff and Backhaus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Last observation carried forward (LOCF) prediction of recovery per assessment over the time course of 1 year, cross-fading the underlying raw values. The solid black line represents the predicted recovery pattern, based on log-transformed difference in means (MNLN) within the confidence interval of the prediction (dashed lines). The green horizontal line resembles a healthy score, respective to 100% recovery. The gray dots represent the underlying data points, with the size depicting the sample size of the respective data point. How these underlying data points are related is presented in Supplementary Figure 1. ARAT, Action Research Arm Test; BBT, Box and Block test; F-M, Fugl–Meyer Assessment (upper extremity); GRIP, grip force; MI, Motricity Index; PEG, peg test; RMA, Rivermead Motor Assessment; SIS, Stroke Impact Scale; WMFT, Wolf Motor Function Test.