TABLE 1.
hAM or ACM | Indication | No. of patients | Graft storage format | Graft size (mm)/Side | Multilayered use/folding | Pre- and post-surgical care | Fate/Resorption | References and year |
hAM | Gingival recession | 1 | Lyophilized or dehydrated | Adapted to size of defect | No | Mouth rinses with Chlorhexidine | ND | Shetty et al., 2014 |
Gingival recession | 3 | Dehydrated and sterilized | Adapted to size of defect | No | Antibiotics No tooth brushing for 3 weeks Mouth rinses with Chlorhexidine for 3 weeks | ND | Sharma and Yadav, 2015 | |
Gingival recession | 15 | Lyophilized and irradiated (rq: dehydrated written in title) | 10 × 10 mm (?) (rq: written 1 × 1 mm in the article) | No | Mouth rinses with Chlorhexidine just before surgery and continued after surgery | Improvement in width of keratinized gingiva at 3 months and 6 months | Jain et al., 2017 | |
Gingival recession | 10 | Lyophilized and irradiated | Adapted to size of gingival recession | No | Pre-surgical mouth rinses with Chlorhexidine Mouth rinses for 4 weeks No tooth brushing for 4 weeks Suture removal at day 10 | ND | Rehan et al., 2018 | |
Bone defect in the furcation | 5 | Lyophilized and gamma-irradiated | Adapted to size of defect | No | Antibiotics for 1 week Mouth rinses with Chlorhexidine twice a day for 4 weeks Suture removal at day 7 | ND | Kothiwale et al., 2009 | |
Bone defect in the furcation | 1 | Lyophilized and irradiated | Adapted to size of bone defect | No | Antibiotics Mouth rinses with Chlorhexidine for 1 week | ND | Kumar et al., 2017 | |
Bone defect in the furcation | 15 | Dehydrated or lyophilized (?) according to figure 4 in the article | Adapted to size of bone defect | No | Antibiotics for 5 days Mouth rinses with Chlorhexidine 2 times a day for 2 weeks Tooth brushing with a soft toothbrush Suture removal at day 7 | ND | Kaur and Bathla, 2018 | |
Intrabony defect in interproximal areas | 30 | Lyophilized and irradiated | 30 × 30 mm | No | Antibiotics for 1 week Suture removal at 1 week | ND | Kumar et al., 2015 | |
Intrabony defects in interproximal areas | 10 | Lyophilized and irradiated | Adapted to size of defect | Bio-Oss bone allograft covered with a double layer of hAM, with excess folded | Antibiotics for 1 week Mouth rinses with Chlorhexidine for 4 weeks No tooth brushing for 2 weeks, then only using an extra-soft toothbrush Suture removal at 2 weeks | ND | Kiany and Moloudi, 2015 | |
Surgical wound after implant surgery | 15 | Cryopreserved | Adapted to size of wound Mesenchymal side in contact with wound | No | Antibiotics for 1 week Mouth rinses with Chlorhexidine for 2 weeks | At 3 and 6 days: Epithelialization obtained faster on the hAM side than on the standard procedure side | Velez et al., 2010 | |
BRONJ | 2 | Cryopreserved | 30 × 30 mm | No | ND | ND | Ragazzo et al., 2018 | |
ACM | Alveolar ridge preservation | 20 | Deepithelialized and dehydrated (irradiated?) | Adapted to size of defect | No | No antibiotics | Epithelialization in 2 weeks approximately | Hassan et al., 2017 |
Alveolar ridge preservation | 2 | Deepithelialized and dehydrated (irradiated?) | 8 × 8 mm | No | Pre-operative care: mouth rinses with Chlorhexidine for 3 days Antibiotics for 5 days Tooth brushing with tap water | After 1 month: mature epithelium | Cullum and Lucas, 2019 | |
Alveolar ridge preservation | 21 | Dehydrated | Adapted to size of defect | No | Prophylactic antibiotics and mouth rinses with Chlorhexidine before surgery Antibiotics for 10 days Mouth rinses with hydrogen peroxide for 2 weeks | Epithelialization in 2 weeks | Faraj et al., 2020 | |
Peri-implantation wound management | 15 | Deepithelialized, dehydrated and irradiated | Adapted to size of gingiva around implant | No | Avoid injuries Mouth rinses (not with Chlorhexidine) | After 2 weeks: the environment around the implant is covered with keratinized gingiva | De Angelis et al., 2019 | |
Intrabony defect in interproximal area | 1 | Deepithelialized and dehydrated | 25 × 15 mm ACM was cut in half: one half was placed on the root surface. FDBA was covered by the other half | Double layer of ACM around FDBA, the first layer was folded on the grafted bone before applying the second layer | Antibiotics for 1 week Mouth rinses with Chlorhexidine for 2 weeks No tooth brushing for 2 weeks at the site | ND | Hamada et al., 2020 | |
Schneider membrane perforation repair | 9 | Deepithelialized and dehydrated (irradiated?) | Adapted to size of perforation, 3 mm wider | 2 layers with combination of particulate bone allograft and bone xenograft in between | Antibiotics for 10 days Nasal decongestants: Oxymetazoline nasal spray for 3 days, Pseudoephedrine for 1 week | ND | Holtzclaw, 2015 |
Number of applications = 1. ND: not done; ? = information assumed by the authors according to article content; FDBA: freeze-dried bone allograft.