Table 2.
Descriptive characteristics of the exposure and outcome biomarkers in the euthyroid study participants (N=473).
| Class | Biomarker | GM±SD | Median (25th - 75th percentile) |
|---|---|---|---|
| Thyroid Function* | TSH (mU/L) | 1.60 ± 1.6 | 1.63 (1.20 – 2.18) |
| TT3 (ng/dL) | 163.20 ± 1.2 | 163 (147 – 181) | |
| TT4 (μg/dL) | 10.40 ± 1.1 | 10.36 (9.53 – 11.39) | |
| TT3:TT4 ratio (ng/μg) | 15.86 ± 2.3 | 15.81 (14.17 – 17.34) | |
| FT3i (ng/dL) | 162.17 ± 1.1 | 162 (147.07 – 178) | |
| FT4i (μg/dL) | 10.33 ± 1.1 | 10.29 (9.42 – 11.34) | |
| T3 uptake (%) | 27.82 ± 1.1 | 28 (27 – 29) | |
| OPE** (SG-standardized) | DPHP (μg/L) | 0.52 ± 2.8 | 0.55 (0.29 – 0.99) |
| DNBP (μg/L) | 0.28 ± 2.2 | 0.24 (0.17 – 0.40) | |
| BBOEP (μg/L) | 0.09 ± 2.4 | 0.08 (<LOD - 0.15) | |
| BDCIPP (μg/L) | 0.23 ± 2.8 | <LOD (<LOD - 0.30) | |
| Phthalates (SG- and batch-standardized) | MEP (μg/L) | 102.45 ± 4.4 | 101.18 (32.97 – 305.21) |
| MiBP (μg/L) | 18.74 ± 2.5 | 17.07 (9.74 – 32.20) | |
| MnBP (μg/L) | 18.67 ± 2.4 | 17.53 (11.79 – 30.98) | |
| MBzP (μg/L) | 4.68 ± 2.5 | 4.26 (2.56 – 7.85) | |
| MEHP (μg/L) | 11.27 ± 2.1 | 10.28 (7.07 – 16.61) | |
| MEHHP (μg/L) | 14.26 ± 2.5 | 12.89 (8.52 – 21.13) | |
| MEOHP (μg/L) | 9.60 ± 2.4 | 8.78 (5.71 – 14.37) | |
| MECPP (μg/L) | 21.08 ± 2.0 | 18.61 (14.06 – 25.84) | |
| MMCHP (μg/L) | 21.22 ± 1.9 | 18.33 (14.07 – 26.89) | |
| ∑DEHP (mmol/L) | 0.27 ± 2.0 | 0.24 (0.18 – 0.34) | |
| OH-MiNP (μg/L) | 1.07 ± 2.1 | 0.95 (0.69 – 1.44) | |
| oxo-MiNP (μg/L) | 1.24 ± 2.4 | 1.04 (0.70 – 1.78) | |
| cx-MiNP (μg/L) | 3.69 ± 1.7 | 3.54 (2.46 – 4.77) | |
| ∑DiNP (mmol/L) | 0.02 ± 1.9 | 0.02 (0.01 – 0.03) |
Arithmetic mean and standard deviation presented instead of GM ± SD.
DPHP LOD: 0.03 (97%>LOD); DNBP LOD: 0.07 (94%>OD); BBOEP LOD: 0.05 (52%>LOD); BDCIPP LOD: 0.17 (21%>LOD).
Notes: only OPE metabolites were measured below LOD for some participants, and therefore was substituted with LOD/√2.
Abbreviations: triiodothyronine, T3; thyroxine, T4; Thyroid stimulating hormone, TSH; Diphenyl phosphate, DPHP; Di-n-butyl phosphate, DnBP; Bis(2-butoxyethyl) hydrogen phosphate, BBOEP; Bis(1,3-dichloro-2-propyl) phosphate, BDCIPP; specific gravity, SG; geometric mean, GM; geometric standard deviation, SD; monoethyl phthalate, MEP; mono-iso-butyl phthalate, MiBP; mono-n-butyl phthalate, MnBP; monobenzyl phthalate, MBzP; molar sum of di(2-ethylhexyl)phthalate metabolites, ∑DEHP; molar sum of di-iso-nonyl phthalate metabolites, ∑DiNP