Table 2.
Multiple cellular processes of HDAC5 in cancer management.
| Tumor type | Expression status | Target genes | Effect upon cell lines | References |
|---|---|---|---|---|
| Breast Cancer | Up-regulation | LSD1 | Increase cell metastasis and invasion | (50) |
| Up-regulation | p53 | inhibit cell proliferation | (51) | |
| Up-regulation | RUNX3 | increase cell stemness | (46) | |
| Up-regulation | SOX9 | increase chemoresistance | (52) | |
| Up-regulation | miR-125a-5p, Sp1, survivin | increase chemoresistance | (53) | |
| Neuroblastoma | Up-regulation | CD9 | Increase cell metastasis and invasion | (54) |
| Up-regulation | N-myc | promote cell proliferation | (55) | |
| Up-regulation | N-myc | block cell differentiation | (55) | |
| Medulloblastoma | Up-regulation | caspase-3 | inhibit cell apoptosis | (56) |
| Lung Cancer | Up-regulation | DLL4, Six1, Notch1, Twist1 | promote cell proliferation | (22) |
| Colorectal Cancer | Up-regulation | DLL4 | promote cell proliferation | (57) |
| Osteosarcoma | Up-regulation | Twist | promote cell proliferation | (30) |
| Up-regulation | N/A | maintain long telomeres’ length | (58) | |
| Fibrosarcoma | Up-regulation | N/A | maintain long telomeres’ length | (58) |
| Wilms’ tumor | Up-regulation | c-Met | promote cell proliferation | (31) |
| Glioma | Up-regulation | Notch1 | promote cell proliferation | (29) |
| Hepatocellular carcinoma | Up-regulation | Six1 | promote cell proliferation | (59) |
| Up-regulation | p21, cyclin D1, CDK2/4/6 | promote cell cycle | (60) | |
| Up-regulation | p53, Bax, cyto C, caspase-3, Bcl-2 | inhibit cell apoptosis | (60) | |
| Urothelial Carcinoma | Down-regulation | TGF-β | hinder cell proliferation | (61) |
| Lymphoma | Up-regulation | TNF-α, MCP-1 | induce pro-inflammatory function | (62) |
| Pancreatic Cancer | Up-regulation | Socs3, CCL2, TGF-β | promote macrophage recruitment | (63) |
| Ovarian Cancer | Up-regulation | YY1, miR-99a | increase cell stemness | (64) |