Table 4.
Summary of HDAC5-targeted drugs in cancer therapy.
| Agents | Anti-tumor properties | Reference |
|---|---|---|
| Trichostatin A (TSA) | Inhibit proliferation of gastric cancer | (25) |
| Reduce chemoresistance of cancer | (120) | |
| Inhibit proliferation of breast cancer | (124) | |
| Induce apoptosis in breast cancer | (46) | |
| Belinostat (PXD101) | Block chemoresistance in estrogen receptor positive breast cancer | (119) |
| Sodium butyrate | Inhibit migration and EMT in HCC | (71) |
| Panobinostat (LBH589) | Suppress invasion and metastasis in neuroblastoma | (54) |
| Decrease cell viability and proliferation declined,and increase apoptosis and autophagy in HCC | (74) | |
| Vorinostat | Reduce chemoresistance of cancer | (120) |
| Luotonin-A | Cause apoptosis and senescence in Hela cells | (17) |
| Formononetin | Prevent EMT in glioma | (73) |
| LMK-235 | Reduce chemoresistance of cancer | (120) |
| Induce apoptosis of pNET | (125) | |
| Induce apoptosis and reduce proliferation and migration of breast cancer | (20) | |
| Inhibit proliferation, metastasis and invasion of breast cancer | (65) | |
| Inhibit stemness of lung cancer | (93) | |
| AR-42 | Induce apoptosis in HCC | (121) |
| Vorinostat (SAHA) | Induce apoptosis in breast cancer | (122) |
| Ebselen | Decrease cell viability of cancer cells | (123) |
| Sulforaphane | Inhibit proferation of breast cancer | (113) |
| Simvastatin | Suppress proliferation of pancreatic cancer | (66) |
| Inhibit proliferation of CRC | (126) |